Table 4.

Cumulative effect of unfavorable genotypes on overall survival in Chinese patients with hepatocellular carcinoma (n = 448)

Group†	Death/total	HR‡ (95% CI)	P-value§
Group 1 (0)	188/259	Ref.
Group 2 (1)	101/127	1.41 (1.10–1.82)	0.007
Group 3 (2)	39/47	2.09 (1.46–2.97)	<0.001
P for trend			<0.001

^†Patients were grouped by the number of unfavorable genotypes (0–2) in single nucleotide polymorphisms rs1053096 (VV) and rs2305160 (WV+VV) in the NPAS2 gene.

^‡Hazard ratios (HRs) were adjusted by age, sex, hepatitis B virus infection, portal vein tumor thrombus, tumor stage, serum α-fetoprotein, and treatment.

^§Significant P-values (<0.05) are in bold. CI, confidence interval; Ref. reference.