Table 5.
Haplotype and diplotype analysis of rs1053096 and rs2305160 single nucleotide polymorphisms in the NPAS2 gene in Chinese patients with hepatocellular carcinoma (n = 448)
| Group | Frequency,% | Death, n (%) | HR† (95% CI) | P-value‡ |
|---|---|---|---|---|
| Haplotype | ||||
| C-G | 56.0 | 359 (54.7) | Ref. | |
| T-G | 26.7 | 177 (27.0) | 1.04 (0.87–1.24) | 0.680 |
| T-A | 16.4 | 114 (17.4) | 1.59 (1.28–1.97) | <0.001 |
| Other groups | 0.9 | 6 (0.9) | 0.81 (0.36–1.83) | 0.610 |
| Diplotype | ||||
| C_C-G_G | 30.5 | 97 (29.6) | Ref. | |
| C_T-G_G | 29.3 | 91 (27.7) | 0.88 (0.66–1.18) | 0.390 |
| C_T-G_A | 19.9 | 68 (20.7) | 1.50 (1.08–2.08) | 0.010 |
| T_T-G_A | 8.8 | 32 (9.8) | 1.94 (1.29–2.92) | 0.001 |
| T_T-G_G | 7.6 | 27 (8.2) | 1.16 (0.75–1.80) | 0.490 |
| Other groups | 3.9 | 13 (4.0) | 1.22 (0.67–2.21) | 0.510 |
†
Adjusted by age, sex, hepatitis B virus infection, portal vein tumor thrombus, tumor stage, serum α-fetoprotein, and treatment.
‡
Significant P-values (<0.05) are in bold. CI, confidence interval; HR, hazard ratio; Ref., reference.