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. 2014 Jun 18;105(7):749–754. doi: 10.1111/cas.12431

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Volcano plots for differential DNA methylation status. The x-axis shows the mean DNA methylation (Beta-value) difference, whereas the y-axis shows the –log10 of the P-value for each CpG site, representing the strength of association. Eighty-seven differentially methylated CpG sites in hepatitis B core antibody (HbcAb) (−) liver tissues and 603 CpG sites in HBcAb (+) liver tissues in comparison with normal control (NC) liver tissues using (Beta-value difference >0.2, P < 0.05) are plotted in red.