Table 1.
Thirty CpG sites corresponding to 14 gene promoters that were commonly hyper- or hypomethylated in both hepatitis B core antibody (HbcAb) (−) and HBcAb (+) liver tissue samples
| Gene name | Target ID | Chromosome | Position† | HBcAb (−) versus NC | HBcAb (+) versus NC | ||
|---|---|---|---|---|---|---|---|
| Mean difference‡ | P-value | Mean difference‡ | P-value | ||||
| Hypermethylated | |||||||
| CD80 | cg21139795 | 3 | 119243933 | 0.224 | 0.025 | 0.270 | 0.005 |
| NPBWR1 | cg26205771 | 8 | 53851156 | 0.272 | 0.039 | 0.300 | 0.002 |
| CD44 | cg13332350 | 11 | 35239907 | 0.392 | 0.011 | 0.471 | 0.004 |
| USP2 | cg10904972 | 11 | 119227328 | 0.249 | 0.005 | 0.267 | 0.001 |
| TTC9 | cg23691406 | 14 | 71112909 | 0.348 | 0.033 | 0.351 | 0.032 |
| CCDC64B | cg27519622 | 16 | 3079877 | 0.213 | 0.043 | 0.324 | 0.001 |
| SOX9 | cg01524174 | 17 | 70119015 | 0.207 | 0.030 | 0.330 | 0.001 |
| SRC | cg25431463 | 20 | 36012946 | 0.203 | 0.027 | 0.219 | 0.003 |
| Hypomethylated | |||||||
| RPS6KA1 | cg24585377 | 1 | 26857774 | −0.216 | −0.216 | −0.203 | 0.002 |
| PTPN14 | cg11188103 | 1 | 214668616 | −0.228 | −0.228 | −0.209 | 0.005 |
| TRIM10 | cg08094206 | 6 | 30122523 | −0.276 | −0.276 | −0.278 | 0.002 |
| PDGFA | cg14496282 | 7 | 544525 | −0.252 | −0.252 | −0.325 | 0.001 |
| ATP11A | cg08464505 | 13 | 113425982 | −0.217 | −0.217 | −0.250 | 0.001 |
| DEGS2 | cg23076361 | 14 | 100622050 | −0.201 | −0.201 | −0.200 | 0.001 |
†
Positions refer to Genome Research Consortium human genome build 37 (GRCh37)/UCSC human genome 19 (hg19).
‡
Mean difference of Beta-values between HBcAb (−) or HBcAb (+) and normal control liver tissues.