Table 2.
Standardized incidence ratios (SIR) of second primary cancers according to sites of first and second primary cancers arranged by SIRs > or <1
| First cancer site | Second cancer site | Observed | Expected | SIR | 95% CI |
|
|---|---|---|---|---|---|---|
| Lower | Upper | |||||
| SIR > 1 (P < 0.05) | ||||||
| Mouth/pharynx | Esophagus | 77 | 6 | 12.67 | 10.00 | 15.84 |
| Mouth/pharynx | Liver | 39 | 19 | 2.02 | 1.44 | 2.76 |
| Mouth/pharynx | Lung | 57 | 38 | 1.51 | 1.14 | 1.95 |
| Mouth/pharynx | Thyroid | 9 | 2 | 4.40 | 2.01 | 8.36 |
| Esophagus | Mouth/pharynx | 51 | 4 | 12.33 | 9.18 | 16.21 |
| Esophagus | Stomach | 148 | 39 | 3.82 | 3.23 | 4.49 |
| Esophagus | Liver | 26 | 17 | 1.55 | 1.01 | 2.27 |
| Esophagus | Larynx | 14 | 2 | 6.74 | 3.68 | 11.31 |
| Esophagus | Lung | 47 | 34 | 1.39 | 1.02 | 1.85 |
| Stomach | Esophagus | 134 | 79 | 1.70 | 1.43 | 2.02 |
| Stomach | Colorectum | 891 | 658 | 1.35 | 1.27 | 1.45 |
| Colorectum | Stomach | 751 | 547 | 1.37 | 1.28 | 1.47 |
| Colorectum | Pancreas | 137 | 113 | 1.21 | 1.02 | 1.43 |
| Colorectum | Ovary | 34 | 19 | 1.83 | 1.27 | 2.56 |
| Colorectum | Kidney/urinary tract/bladder | 235 | 195 | 1.20 | 1.06 | 1.37 |
| Liver | Stomach | 170 | 118 | 1.44 | 1.23 | 1.67 |
| Liver | Thyroid | 15 | 5 | 3.29 | 1.84 | 5.43 |
| Pancreas | Esophagus | 9 | 4 | 2.49 | 1.14 | 4.74 |
| Pancreas | Stomach | 42 | 30 | 1.41 | 1.02 | 1.91 |
| Larynx | Mouth/pharynx | 22 | 3 | 6.69 | 4.19 | 10.13 |
| Larynx | Esophagus | 22 | 5 | 4.67 | 2.93 | 7.07 |
| Larynx | Stomach | 47 | 32 | 1.49 | 1.09 | 1.98 |
| Larynx | Colorectum | 49 | 33 | 1.49 | 1.10 | 1.97 |
| Larynx | Lung | 75 | 29 | 2.60 | 2.04 | 3.25 |
| Larynx | Thyroid | 5 | 1 | 6.66 | 2.15 | 15.54 |
| Lung | Thyroid | 39 | 9 | 4.55 | 3.24 | 6.22 |
| Breast (females) | Lung | 90 | 64 | 1.41 | 1.13 | 1.73 |
| Breast (females) | Uterus | 75 | 53 | 1.41 | 1.11 | 1.77 |
| Breast (females) | Ovary | 34 | 19 | 1.83 | 1.27 | 2.56 |
| Breast (females) | Thyroid | 36 | 17 | 2.07 | 1.45 | 2.87 |
| Uterus | Lung | 77 | 40 | 1.91 | 1.50 | 2.38 |
| Uterus | Kidney/urinary tract/bladder | 28 | 16 | 1.79 | 1.19 | 2.59 |
| Ovary | Colorectum | 32 | 18 | 1.79 | 1.22 | 2.52 |
| Ovary | Uterus | 41 | 8 | 5.08 | 3.64 | 6.89 |
| Prostate | Kidney/urinary tract/bladder | 128 | 72 | 1.78 | 1.49 | 2.12 |
| Kidney/urinary tract/bladder | Lung | 218 | 169 | 1.29 | 1.12 | 1.47 |
| Kidney/urinary tract/bladder | Prostate | 187 | 98 | 1.91 | 1.64 | 2.20 |
| Thyroid | Lung | 40 | 22 | 1.83 | 1.31 | 2.49 |
| Blood | Thyroid | 19 | 6 | 3.15 | 1.89 | 4.91 |
| SIR < 1 (P < 0.05) | ||||||
| Stomach | Prostate | 246 | 284 | 0.87 | 0.76 | 0.98 |
| Liver | Lung | 64 | 99 | 0.65 | 0.50 | 0.82 |
| Liver | Prostate | 36 | 52 | 0.69 | 0.48 | 0.96 |
| Liver | Kidney/urinary tract/bladder | 24 | 39 | 0.61 | 0.39 | 0.91 |
| Gallbladder | Lung | 22 | 40 | 0.55 | 0.34 | 0.83 |
| Gallbladder | Prostate | 8 | 17 | 0.48 | 0.21 | 0.95 |
| Pancreas | Blood | 2 | 10 | 0.19 | 0.02 | 0.70 |
| Lung | Liver | 70 | 92 | 0.76 | 0.59 | 0.96 |
| Lung | Gallbladder | 26 | 43 | 0.60 | 0.39 | 0.88 |
| Lung | Prostate | 79 | 109 | 0.72 | 0.57 | 0.90 |
| Prostate | Esophagus | 9 | 25 | 0.36 | 0.17 | 0.69 |
| Prostate | Stomach | 150 | 178 | 0.84 | 0.71 | 0.99 |
| Prostate | Liver | 48 | 69 | 0.70 | 0.52 | 0.93 |
| Prostate | Lung | 152 | 180 | 0.85 | 0.72 | 0.99 |
| Prostate | Blood | 38 | 60 | 0.63 | 0.45 | 0.87 |
| Thyroid | Gallbladder | 1 | 8 | 0.13 | 0.00 | 0.74 |
CI, confidence interval.