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. 2014 Jun 27;105(7):833–839. doi: 10.1111/cas.12432

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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(a) Relation of histological findings and degree of relative hemoglobin (rtHb). A significantly higher mean rtHb value is observed in mucinous carcinoma (Muc; 2.8 ± 0.8 SD) than in normal breast rtHb (N; 1.1 ± 0.1 SD, P = 0.001). Mean rtHb was not significantly different between normal breasts and other histological types, ductal carcinoma in situ (DCIS; 1.4 ± 0.6 SD, P = 0.3) and invasive ductal carcinoma (IDC; 1.7 ± 1.1 SD, P = 0.2). Invasive lobular carcinoma (ILC) had relatively higher rtHb (2.1) whereas lobular carcinoma in situ (LCIS) had low rtHb (1.1) compared to a normal breast. Angiosarcoma (Angio) showed remarkably high rtHb (19.1). (b) Relationship of histological findings and degree of tumor tissue oxygen saturation (stO₂). There were no significant differences in mean stO₂ values between normal breast (N; 70.8 ± 1.7% SD) and other histological types, DCIS (66.2 ± 6.6% SD, P = 0.1), IDC (69.5 ± 4.5% SD, P = 0.5), and mucinous carcinoma (Muc; 61.8 ± 8.8% SD, P = 0.06).