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. 2014 Nov 5;105(12):1519–1525. doi: 10.1111/cas.12551

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig. 2 — Effect of etoposide-induced double-strand breaks (DSBs) during mitosis on genomic instability of mitotic chromosomes. Representative images of chromosome spreads from etoposide-treated (+Etoposide) and non-treated (−Etoposide) in HCT116 human colon cancer cells arrested in mitosis. Arrows indicate dicentric chromosomes. Arrowheads show fragmented chromosomes. Scale bar = 10 μm.