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The 5y-RFS of patients with 13th JGCA pathological stage IIIB tumors with the indicated RTK expression, as detected using IHC, was analyzed using Kaplan Meier survival curves. The 5y-RFS of patients with HER3 and EphA2 overexpression was statistically significantly different from that of patients with no HER3 or EphA2 expression respectively (HER3; P = 0.019, EphA2; P = 0.042). EGFR, HER2 and IGF-1R overexpression also tended to indicate poor prognosis in 13th JGCA stage IIIB tumors.
