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. 2014 Nov 5;105(12):1550–1559. doi: 10.1111/cas.12554

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig. 5 — Angiopoietin-like protein 2 (ANGPTL2) positively regulates itself by activating the spleen tyrosine kinase–nuclear factor of activated T cells (Syk–NFAT) pathway in colorectal cancer cells. (a) Relative mRNA expression of NFAT family members in SW480/Ctrl, SW480/ANGPTL2-1, or SW480/ANGPTL2-2 cells (n = 3). (b) Nuclear translocation of NFATc3 in SW480/Ctrl or SW480/ANGPTL2-1 cells. Nuclei were counterstained with DAPI. Arrowheads indicate overlap of NFATc3 and DAPI staining. Scale bar = 50 μm. (c) Relative expression of endogenous ANGPTL2 mRNA in SW480/Ctrl or SW480/ANGPTL2-1 cells, either non-treated (control) or treated with the NFAT inhibitor cyclosporin A (CsA) (n = 3). Data from non-treated SW480/Ctrl cells was set at 1. Error bars show SEM. **P < 0.01.