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Dissolution curves of glibenclamide powder and typical glibenclamide formulations comprising various fractions of HPMCE5 (H), PEG6000 (P), and Poloxamer407 (X), prepared by SE method. A fixed 1:10 weight ratio of glibenclamide to the carrier system was used in all experiments. Each formulation is represented as a three-letter code with numbers indicating the fraction of each component in the carrier mixture, where H+P+X=100% (10).
