Table 1. Treatment of Restless Leg Syndrome.
Level of Disorder (Medication) | Level of Recommendation |
---|---|
Mild to Intermittent | |
Dopamine Agonists | Standard level |
Levodopa | Guideline level |
Benzodiazepine | Option level |
Low-Potent Opioid | Guideline level (but off-label use) |
Disabling and Persistent | |
Dopamine Agonist | |
Alpha-2-Delta Calcium Channel Ligands | |
Gabapentin | Guideline level |
Gabapentin Enacarbil | |
Pregabalin | |
Refractory | |
Dopamine Agonists | |
Levodopa | |
Gabapentin, Gabapentin Enacarbil | |
Opioid (Oxycodone, Hydrocodone, and Methadone) | |
Clonidine | Option level |
Carbamazepine | Option level |
Propranolol | Option level |
Uremic Restless Leg Syndrome | |
Gabapentin | |
Ropinirole | |
Pramipexole | |
Levodopa | |
Benzodiazepines | |
Intravenous Iron Dextran | |
Additional Therapies | |
Nonpharmacologic Therapies | |
Iron Therapy If Ferritin Level < 75 μg/L |