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. 2014 Sep 5;6(5):e22009. doi: 10.5812/numonthly.22009

Table 1. Treatment of Restless Leg Syndrome.

Level of Disorder (Medication) Level of Recommendation
Mild to Intermittent
Dopamine Agonists Standard level
Levodopa Guideline level
Benzodiazepine Option level
Low-Potent Opioid Guideline level (but off-label use)
Disabling and Persistent
Dopamine Agonist
Alpha-2-Delta Calcium Channel Ligands
Gabapentin Guideline level
Gabapentin Enacarbil
Pregabalin
Refractory
Dopamine Agonists
Levodopa
Gabapentin, Gabapentin Enacarbil
Opioid (Oxycodone, Hydrocodone, and Methadone)
Clonidine Option level
Carbamazepine Option level
Propranolol Option level
Uremic Restless Leg Syndrome
Gabapentin
Ropinirole
Pramipexole
Levodopa
Benzodiazepines
Intravenous Iron Dextran
Additional Therapies
Nonpharmacologic Therapies
Iron Therapy If Ferritin Level < 75 μg/L