Tab. 6.
Mean pharmacokinetic parameters of atorvastatin in the absence and presence of pioglitazone (PIO) and cholestyramine (CSA) in Wistar rats
| Parameter | Atorvastatin (Control) | Atorvastatin (PIO) | Atorvastatin (CSA) | Pioglitazone (Control) | Pioglitazone (ATR) |
|---|---|---|---|---|---|
| AUC(0-t) (ng.h/mL) | 884±98 | 879±92 | 756±79 | 8060±1073 | 7817±938 |
| AUC(0-∞) (ng.h/mL) | 1005±138 | 1003±127 | 860±83 | 8427±1121 | 8155±1035 |
| Cmax(ng/mL) | 94.4±27.9 | 89.7±27.3 | 74.6±22.1 | 1064.0±372.9 | 981.6±354.6 |
| Tmax (h) | 2.0 | 2.0 | 2.0 | 3.0 | 3.0 |
| T1/2 | 6.23±1.92 | 6.69±2.18 | 7.04±2.13 | 4.78±2.34 | 5.09±3.05 |
| Kel (h-) | 0.119±0.038 | 0.111±0.037 | 0.105±0.032 | 0.124±0.039 | 0.132±0.042 |
Data are derived from the mean of six animals and are shown as the mean± SD.
All the data points are not statistically different with respect to the control (p < 0.05).