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. 2015 Jan 21;12(1):1. doi: 10.1186/s12989-014-0078-9

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© Delaval et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Experimental design. C57Bl/6j mice were intranasally instilled with silica nanoparticles (5 mg/Kg) or vehicle and 5 h post NPs instillation infected with P.aeruginosa by intranasal instillation. 18 h after infection, inflammatory markers in the lungs were analysed by measuring cytokines and neutrophil recruitment in the broncho-alveolar lavages (BALs). Bacterial loads were studied by bioluminescence after infection with a Pa-luciferase producing strain. Distribution of fluorescently labelled FITC SiO₂ NPs (Fate of NPs) was followed by immunofluorescence analysis of cells present in BALs and lung tissues.