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. Author manuscript; available in PMC: 2015 Feb 5.
Published in final edited form as: Oral Oncol. 2014 Jun 2;50(9):771–779. doi: 10.1016/j.oraloncology.2014.05.004

Figure 5.

Figure 5

Algorithms using multimodality methods of HPV detection generally begin with p16 immunohistochemical staining. In situ hybridization assays and/or PCR-based assays are used in p16 positive carcinomas to confirm the presence of HPV.