Table 1.
HIV: Human Immunodeficiency Virus; SD: Standard Deviation; IQR: Interquartile Range; ART: Antiretroviral Therapy; μL: Microliter; BD: Bronchodilator; FEV1: Forced Expiratory Volume in 1 second; FVC: Forced Vital Capacity; DLCO: Diffusing Capacity for Carbon Monoxide.
| Characteristic | (Men’s) Multicenter AIDS Cohort Study (n=121) | Women’s Interagency HIV Study (n=63) |
|---|---|---|
| Age, mean (SD) | 53.1 (7.5) | 49.1 (8.9) |
| Female, n (%) | 0 (0) | 63 (100) |
| Race, n (%) | ||
| White | 100 (82.6) | 23 (36.5) |
| Black | 21 (17.4) | 40 (63.5) |
| Hispanic, n (%) | 3 (2.5) | 5 (7.9) |
| Completed high school, n (%) | 114 (94.2) | 47 (74.6) |
| Marital status, n (%) | ||
| Never married | – | 21 (33.3) |
| Married | – | 22 (34.9) |
| Divorced or widowed | – | 20 (31.8) |
| Alcohol consumption, n (%) | ||
| None | 69 (57.0) | 38 (60.3) |
| 1–2 drinks per week | 22 (18.2) | 16 (25.4) |
| >2 drinks per week | 30 (24.8) | 9 (14.3) |
| Clinical History | ||
| Number of study visits attended, mean (SD) | 35 (16.0) | 26 (6.3) |
| Tobacco use, n (%) | ||
| Never | 26 (21.5) | 12 (19.1) |
| Former | 58 (47.9) | 23 (36.5) |
| Current | 37 (30.6) | 28 (44.4) |
| Cumulative pack-years tobacco use, median (IQR) | 8.2 (0–33.2) | 3.0 (0.04–12.4) |
| Asthma diagnosis, n (%) | 15 (12.4) | 22 (34.9) |
| Bronchodilator use in previous 3 months, n (%) | 12 (9.9) | 11 (17.5) |
| Hepatitis C infection, n (%) | 13 (10.7) | 30 (47.6) |
| History of bacterial or Pneumocystis jirovecii pneumonia, n (%) | 40 (33.1) | 14 (22.2) |
| ART use since last visit, n (%) | 104 (86.0) | 51 (81.0) |
| Current CD4 (cells/μL), median (IQR) | 575 (440–794) | 426 (264–677) |
| Nadir CD4 (cells/μL), median (IQR) | 269 (155–358) | 159 (65–286) |
| Current HIV RNA level (copies/mL), median (IQR) | <40 (40–40) | 102 (48–727) |
| Recreational Drug Use | ||
| Percentage of total visits reporting recent drug use, median % (IQR) | 56 (18–87) | 31 (3–75) |
| Any drug use since last visit, n (%) | 59 (48.8) | 25 (39.7) |
| Pulmonary Function | ||
| Airflow obstruction | ||
| Post-BD FEV1/FVC ratio <0.70, n (%) | 16 (13.2) | 7 (11.1) |
| Post-BD FEV1/FVC ratio, mean (SD) | 0.78 (0.08) | 0.78 (0.07) |
| Diffusion impairment | ||
| DLCO % predicted <80%, n (%) | 65 (53.7) | 53 (84.1) |
| DLCO % predicted <60%, n (%) | 16 (13.2) | 23 (36.5) |
| DLCO % predicted, mean (SD) | 79 (19.0) | 65 (14.0) |
| Radiographic emphysema,b n (%) | 64 (65.3) | 9 (15.3) |
a
: Survey questions differ between MACS and WIHS. Unavailable data represented with “–”.
b
: CT data available for 98 men and 59 women. Radiographic emphysema defined as >1% of lung voxels <−950 Hounsfield units.