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. Author manuscript; available in PMC: 2016 Feb 3.
Published in final edited form as: Cell Metab. 2015 Feb 3;21(2):195–205. doi: 10.1016/j.cmet.2014.12.019

Figure 3. Relationship of mitochondrial dynamism to mitophagy.

Figure 3

Mitochondria accumulate damage over time. Impaired (partially depolarized) mitochondrion divides into one depolarized daughter and one hyperpolarized daughter through asymmetric fission. The depolarized daughter is eliminated via Mfn2-Parkin-mediated mitophagy and the hyperpolarized daughter re-joins the functional mitochondrial pool through organelle fusion. Healthy mitochondria (hyperpolarized) are colored in green and damaged mitochondria (depolarized) in yellow.