Table 1.
Identification of CTCs and BM-DTCs in BC PDX lines and previously reported presence of LM
| PDX line | CTC detection rate (%) | Number of CTCs per 20 K nucleated cells (≈20 μl of blood) | BM-DTC detection rate (%) | Number of BM-DTCs per 2 × 10 6 BM cells | LM rate [26] (%) |
|---|---|---|---|---|---|
| BCM-3107* | 1/4 (25) | 7 | 1/2 (50) | 1 | 0 |
| BCM-3143 | 0/2 (0) | 0 | 0/2 (0) | 0 | 0 |
| BCM-3204* | 2/4 (50)Cl | 3-43 | 0/2 (0) | 0 | 29 |
| BCM-3561* | 2/4 (50) | 1 | ND | ND | 0 |
| BCM-3613* | 1/3 (33) | 7 | 0/2 (0) | 0 | 24 |
| BCM-3807 | 0/4 (0) | 0 | 1/2 (50) | 29 | 0 |
| BCM-3887* | 3/4 (75)Cl | 3-92 | 1/5 (20) | <1 | 14 |
| BCM-3963* | 1/6 (17) | 7 | 0/4 (0) | 0 | 14 |
| BCM-4195 | 0/2 (0) | 0 | 0/2 (0) | 0 | 0 |
| BCM-4272* | 3/3 (100) | <1-25 | 4/6 (67)Cl | <1-132 | 29 |
| BCM-4664* | 1/3 (33) | 2 | ND | ND | 0 |
| BCM-4888* | 5/5 (100)Cl | 3-28 | 0/4 (0) | 0 | 67 |
| BCM-5097 | 3/6 (50)Cl | 10-91 | 3/5 (60) | 12-30 | 36 |
| BCM-5156 | 3/5 (60) | 1-28 | 1/2 (50) | 2 | 0 |
| BCM-5438 | 2/2 (100) | 2-3 | 2/2 (100) | 4-67 | 0 |
| BCM-5471 | 3/6 (50)Cl | 1-10 | 2/4 (50)Cl | <1-6 | 33 |
| BCM-5998 | 5/7 (71) | <1-27 | 6/8 (75)Cl | 1-40 | 0 |
| BCM-6257 | 3/3 (100)Cl | 3-4 | 2/3 (67)Cl | 22-39 | 6 |
BC, breast cancer; BM, bone marrow; BM-DTCs, disseminated tumor cells in bone marrow; CTC,s circulating tumor cells, LM, lung metastasis, ND, not determined, PDX, patient-derived xenograft. Cl represents presence of CTCs and BM-DTCs in clusters. * indicates the lines with published Affymetrix data.