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. 2015 Jan 5;7(1):2. doi: 10.1186/1866-1955-7-2

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© Fehr et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Schematic representation of the CDKL5 protein and our mutational grouping. Legend: The catalytic region is shown in light grey and the C-terminal region in white. Modified from ‘What We Know and Would Like to Know about CDKL5 and its Involvement in Epileptic Encephalopathy’ [17]. TEY motif Thr-Glu-Tyr motif, NLS ₁ and NLS ₂ nuclear localisation signals 1 and 2, NES nuclear export signal.