Table 2.

Univariate and Multivariate Analysis of Predictors of Optimal Morphologic and Major Pathologic Response

Factor	Morphologic Response					Pathologic Response
	Optimal Response (n = 52) (%)	Univariate Analysis P Value	Multivariate Analysis			Major Response (n = 100) (%)	Univariate Analysis P Value	Multivariate Analysis
			P	OR	95% CI			P	OR	95% CI
DFI, years
<1 (n = 122)	34 (27.9)	.868				61 (50)	.097
≥1 (n = 62)	18 (29)					39 (62.9)
Primary tumor location
Rectum (n = 37)	11 (29.7)	.824				19 (51.4)	.682
Colon (n = 147)	41 (27.9)					81 (55.1)
Primary tumor nodal status
Positive (n= 132)	36 (27.3)	.635				67 (50.8)	.119
Negative (n = 52)	16(30.8)					33 (63.5)
Preoperative chemotherapy
>6 cycles (n = 66)	14(21.2)	.112				35 (53)	.788
≤6 cycles (n = 118)	38 (32.2)					65 (55.1)
Multiple CLM
Yes (n = 122)	36 (29.5)	.598				66 (54.1)	.924
No (n = 62)	16(25.8)					34 (54.8)
Largest CLM at diagnosis
≤3 cm (n = 72)	26 (36.1)	.058	.044	1.98	1.02-3.87	46 (63.9)	.037	.009	2.39	1.25-4.59
>3 cm (n = 112)	26 (23.2)					54 (48.2)
RAS mutational status
Wild-type (n = 146)	48 (32.9)	.006	.008	4.38	1.45-13.15	86 (58.9)	.015	.009	2.79	1.29-6.04
Mutant (n = 38)	4 (10.5)					14(36.8)

Abbreviations: OR, odds ratio; DFI, disease-free interval; CLM, colorectal liver metastases.