Table 1.
Peptide | Composition | MW Calc/Found | RT [min] | EC50 [nM] TREX-hFpn-GFP cells |
---|---|---|---|---|
PR73 | C86H133N21O15S | 1733.19/1734.34 | 47.11 | 4.2±0.3 |
PR73SA | C98H151N21O19S | 1959.46/1959.80 | 52.47 | 6.3±1.2 |
PR73SB | C94H143N21O19S | 1903.35/1904.58 | 49.44 | 10.4±1.2 |
PR73SC | C92H139N21O19S | 1875.30/1876.60 | 48.32 | 12.6±1.8 |
PR73SD | C89H135N21O17S | 1803.24/1803.66 | 46.60 | 218.1±13.4 |
PR73SE | C94H140N22O17S2 | 1914.40/1915.02 | 48.52 | 34.0±5.4 |
PR73SF | C96H151N21O19S3 | 1999.56/1999.80 | 52.89* | 10.0±3.4 |
PR73SG | C90H137N23O17S | 1845.28/1846.59 | 49.33* | 8.4±2.5 |
PR73SH | C96H153N21O21P2S | 2031.40/2031.33 | 52.18* | 1.1±0.1 |
Analytical RP-HPLC was performed using an analytical reversed-phase C4 XBridge™ BEH300 column, 4.6×150 mm, 3.5 μm (Waters, Milford, MA), or (*) an analytical reversed-phase C18 SymmetryShield™ column, 4.6×250 mm, 5 μm (Waters, Milford, MA).