Table 3.
Comparison of HR-pQCT Derived MicroFE Bone Strength Parameters Between Obese and Lean Children Matched for Pubertal Stage and Gender Calculated by Paired t-tests and ANCOVA (height as a covariate in the analysis). Significance is Reached at P ≤ .05
| Distal Radius | ||||||
|---|---|---|---|---|---|---|
| Lean (n = 18) Mean (sd) | Obese (n = 18) Mean (sd) | Unadjusted Mean Difference (95% CI) | P Value | Adjusted Mean Difference (95% CI) | P Value | |
| S | 59.76 (10.86) | 61.85 (13.67) | 2.08 (−4.67, 8.83) | .524 | 2.33 (−3.65, 8.32) | .420 |
| F.ult | 3.11 (0.55) | 3.19 (0.67) | 0.08 (−0.25, 0.41) | .606 | 0.10 (−0.20, 0.39) | .497 |
| (Tb.F/TF)dist | 0.57 (0.08) | 0.52 (0.13) | −0.05 (−0.11, 0.01) | .107 | −0.05 (−0.11, 0.01) | .119 |
| (Tb.F/TF)prox | 0.27 (0.07) | 0.24 (0.08) | −0.03 (−0.08, 0.03) | .303 | −0.03 (−0.08, 0.03) | .315 |
| Tb.VM | 5.13 (0.40) | 5.09 (0.77) | −0.04 (−0.36, 0.27) | .770 | −0.04 (−0.34, 0.27) | .803 |
| C.VM | 8.42 (0.26) | 8.45 (0.53) | 0.03 (−0.25, 0.31) | .826 | 0.03 (−0.25, 0.32) | .811 |
| BSI | 14 935 989 (3 097 293) | 16 381 259 (5 483 440) | 1 445 271 (−1 751 750, 4 642 292) | .354 | 1 451 904 (−1 860 145, 4 763 952) | .367 |
| Distal Tibia | ||||||
|---|---|---|---|---|---|---|
| Lean (n = 18) Mean (sd) | Obese (n = 18) Mean (sd) | Unadjusted Mean Difference (95% CI) | P Value | Adjusted Mean Difference (95% CI) | P Value | |
| S | 200.16 (36.08) | 205.15 (40.71) | 4.99 (−14.05, 24.03) | .587 | 5.85 (−9.49, 21.19) | .431 |
| F.ult | 10.38 (1.89) | 10.83 (2.15) | 0.45 (−0.61, 1.52) | .382 | 0.50 (−0.34, 1.34) | .223 |
| (Tb.F/TF)dist | 0.77 (0.08) | 0.75 (0.13) | −0.02 (−0.09, 0.04) | .466 | −0.02 (−0.08, 0.04) | .473 |
| (Tb.F/TF)prox | 0.60 (0.10) | 0.57 (0.14) | −0.02 (−0.10, 0.06) | .588 | −0.02 (−0.08, 0.05) | .580 |
| Tb.VM | 5.52 (0.45) | 5.21 (0.58) | −0.31 (−0.62, −0.001) | .049 | −0.31 (−0.63, 0.01) | .058 |
| C.VM | 7.81 (0.52) | 7.86 (0.61) | 0.05 (−0.29, 0.40) | .761 | 0.04 (−0.28, 0.36) | .797 |
| BSI | 50 468 770 (10 162 836) | 53 876 515 (12 125 229) | 3 407 744.34 (−2 628 317, 9 443 806) | .250 | 3 412 391 (−2 843 083, 9 667 865) | .264 |
S, bone stiffness (kilonewtons per millimeter); F.ult, estimated ultimate failure load (kilonewtons); (Tb.F/TF)dist, ratio of the load taken by the trabeculae in relation to the total load at the distal end; (Tb.F/TF)prox, ratio of the load taken by the trabeculae in relation to the total load at the proximal end; Tb.VM, average von Mises stresses in the trabecular bone (megapascals); C.VM, average von Mises stresses in the cortical bone (megapascals); BSI, bone strength index (mg2/mm4).