Table 1. Profibrotic miRNAs.
| miRNA | Models/site of action | Function | Target genes | Reference |
|---|---|---|---|---|
| miR-33a | TGFβ1-induced HSCs (human) | ↑ Proliferation of HSCs | PPARα | (50) |
| miR-200c | HCV-infected liver (human) | ↑ cSrc signaling cascade | FAP-1 | (51) |
| miR-199a/miR-199a*/miR-199b | CCl4-induced liver fibrosis (human, mouse) | ↑ ECM synthesis | (46) | |
| miR-34a | DMN-induced, CCl4-treated, ethanol-mediated ALD (human, mouse) | ↑ Proliferation | RXRα, ACSL1, CASP2, SIRT1 | (52,53) |
| miR-27a/b | Activated HSC (rat) | ↑ Lipid accumulation and proliferation of HSC | RXRα | (49) |
| miR-21 | PDGF-BB induced HSC, HCV-infected liver, CCl4-treated (human) | ↑ TGFβ signaling | PTEN, Smad7 | (54,55) |
| miR-221/222 | HCV-infected liver (F3-F4), NASH (F3-F4), TAA-induced, HSC, Biliary atresia (human, mouse) | ↑ Col1A1 and MMP-2 expression; ↑ p-AKT and cell proliferation |
CDKN1B, PPP2R2A | (56) |
| miR-181a/b | TGFβ1-induced HSCs (human, rat) | ↑ Cell cycle and proliferation | p27 | (57) |
| miR-214 | HCV-infected liver(F3-F4), MCDD-fed, activated HSC (human, mouse) | ↑ α-SMA, Col1A1, PDGFR-β, FN1, MMP-2, MMP-9, TGFβ1 expression | (58) |