| miR-29 |
IFNα & TGFβ1 stimulated HSC (human, mouse) |
↓ ECM synthesis |
FBN1, ELN1, MMP2, ITGB1, Col1a1, Col1a2, Col4a5, Col5a3 |
(59) |
| miR-150 |
Activated HSC, NASH (rat, human) |
↓ Activation and proliferation in HSC |
c-myb, Col4A4, Sp1 |
(60) |
| miR-132 |
Activated HSC from CCl4-treated, and BDL-livers (mouse) |
↓ PPARγ transcription |
MeCP2 |
(61) |
| miR-122 |
NASH,ALD (human) |
↓ Proliferation and activation of HSCs |
P4HA1 |
(62) |
| miR-335 |
Activated HSC (rat) |
↓ Cell migration |
TNC |
(63) |
| miR-101 |
Activated HSC from CCl4-treated (mouse) |
↓ TGFβ, signaling, apoptosis |
CTGF, TSP-1, KLF6 |
(64) |
| miR-107/miR-449a |
HCV (human) |
↓ NFκB transcription |
YKL40, NOTCH-1 |
(65) |
| miR-200a/b |
TGFβ-induced HSC, CCl4-treated (mouse, rat, human) |
↓ TGFβ dependent EMT, proliferation |
ZEB1/2, TGFβ2, β-catenin |
(66,67) |
| miR-126 |
Activated HSC(rat) |
↓ Migration of HSC |
CRK |
(68) |
| miR-483 |
HSC, CCl4-treated (mouse) |
↓ TGFβ-induced PDGFβ and TIMP2 expression |
Socs3 |
(69) |
| miR-195 |
Activated HSC (human) |
↓ Cell proliferation |
CyclinE1 |
(70) |
| miR-15b/16 |
Activated HSC (rat) |
↑ Apoptosis |
Bcl-2 |
(48) |
| miR-133 |
TGFβ-treated HSC (mouse, human) |
↑ ECM secretion |
Col1A1 |
(71) |
| miR-146a |
CCl4-treated, TGF-β1-treated HSCs (rat) |
↓ Proliferation of HSC |
SMAD4 |
(72) |
| miR-19b |
Activated HSC (rat, human) |
↓ Fibrotic TGF-β signaling |
TGF-βRII |
(43) |
