Fig. 1.

Resequencing of the CDH13 promoter region in the HYPEST and CADCZ sample sets. a Illustrative map of previously identified genetic associations between cardiometabolic traits and SNPs in the CDH13 genomic region (1.17 Mb; GRCh37/hg19 Chr.16: 82,660,399–83,830,215; exons 1–14) is shown at the relative genomic scale. Numbers in superscript indicate the respective publications in the Reference List. b The CDH13 promoter region targeted for resequencing (2,602 bp; Chr.16: 82,659,441–82,662,042; bordered by arrows ‘>’) is zoomed, comprising the 5′ UTR (horizontal box), exon 1 (vertical box) and CpG island (grey box) of the gene. The location of SNPs and the polymorphic (TG)_n microsatellite detected in the current study is shown; population-specific SNPs are marked with ‘*’ (HYPEST) or ‘#’ (CADCZ). CAD coronary artery disease, LDL low-density lipoprotein, SBP systolic blood pressure. ^aWallace et al. (2008); ^bOrg et al. (2009), Fava et al. (2011), Wan et al. (2013); ^cJee et al. (2010); ^dJee et al. (2010), Wu et al. (2010), Jo et al. (2012); ^eJee et al. (2010), Chung et al. (2011); ^fLee et al. (2013); ^gChung et al. (2011), Morisaki et al. (2012), Gao et al. (2013), Uetani et al. (2014); ^hMorisaki et al. (2012), Dastani et al. (2012); ⁱDastani et al. (2012); ^jLee et al. (2013); ^kWellcome Trust Case Control Consortium (2007); ^lLing et al. (2009); ^mLevy et al. (2007)