Table 5.

Results of HYPEST–CADCZ–EGCUT meta-analysis for genetic association tests between common SNPs within the CDH13 promoter region and cardiometabolic traits

SNP	Test allele	Phenotype	Unit	HYPEST		CADCZ		EGCUT		Meta-analysisa
				β (SE) [95 % CI]	P value	β (SE) [95 % CI]	P value	β (SE) [95 % CI]	P value	β (SE) [95 % CI]	P value
rs8060301	A	HDL	mmol/L	0.06 (0.04) [−0.15, 0.03]	1.77 × 10−1	0.09 (0.04) [0.01, 0.16]	2.54 × 10−2	0.07 (0.04) [−0.01, 0.15]	5.82 × 10−2	0.07 (0.02) [0.03, 0.12]	1.25 × 10−3
		DBP	mmHg	0.60 (1.65) [−3.84, 2.64]	7.17 × 10−1	−3.45 (1.29) [−6.00, −0.92]	8.34 × 10−3	−2.31 (1.10) [−4.47, −0.14]	3.69 × 10−2	−2.10 (0.75) [−3.56, −0.63]	4.97 × 10−3
		SBP	mmHg	−1.18 (2.52) [−3.75, 6.12]	6.39 × 10−1	−3.87 (2.17) [−8.12, 0.37]	7.58 × 10−2	−1.71 (1.60) [−4.86, 1.45]	2.87 × 10−1	−2.20 (1.15) [−4.45, 0.04]	5.43 × 10−2
rs12444338	T	HDL	mmol/L	0.04 (0.04) [−0.13, 0.05]	3.67 × 10−1	0.09 (0.04) [0.02, 0.16]	1.44 × 10−2	0.08 (0.04) [0.00, 0.15]	4.99 × 10−2	0.07 (0.02) [0.03, 0.12]	1.51 × 10−3
rs62040565	C	HDL	mmol/L	0.06 (0.04) [−0.14, 0.02]	1.41 × 10−1	0.07 (0.04) [−0.01, 0.14]	8.88 × 10−2	0.03 (0.05) [−0.06, 0.12]	5.10 × 10−1	0.06 (0.02) [0.01, 0.10]	2.36 × 10−2
rs12443878	A	HDL	mmol/L	0.06 (0.04) [−0.14, 0.03]	1.94 × 10−1	0.05 (0.04) [−0.03, 0.12]	2.24 × 10−1	0.03 (0.04) [−0.05, 0.11]	4.13 × 10−1	0.04 (0.02) [−0.01, 0.09]	5.48 × 10−2

SE standard error, CI confidence

^aOnly associations, which demonstrated enhanced significance in meta-analysis compared to all sample-specific tests, are given. Effects and P values are calculated using linear regression, including age and gender as covariates in the model; results were combined using the inverse-variance method under a fixed-effects model. Estimated significance threshold after correction for multiple testing P < 8.33 × 10⁻⁴