FIGURE 6.

The NC domain of PrsA shares a common fold with chaperone domains. A, schematic representation of the PrsA NC domain (cyan) with the body and arms modules, in comparison with the chaperone domains of SurA (red) and trigger factor (yellow), both from E. coli and LIC12922 from Leptospira interrogans (green). Structurally non-conserved regions are represented in gray, whereas conserved ones are highlighted. B, orientation of the PPIase (parvulin) domains (orange), relative to the NC domain. The color code is the same as in A. SurA contains two parvulin domains (ppiase1 and ppiase2). Trigger factor shows a FKBP-type PPIase and a ribosome binding domain (dark gray).