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. 2014 Dec 5;290(6):3377–3389. doi: 10.1074/jbc.M114.608471

FIGURE 7.

FIGURE 7.

Histopathological micrographs of aged tissues. A–F, representative trichrome staining of spleen (A and B), liver (C and D), and heart (E and F) derived from 22-month-old wild type (A, C, and E) or Tpcn2−/− (B, D, and F) mice. Abundant empty vacuoles (B, arrows) from spleen, lipofuscin deposits (D, arrows) from liver, and fibrosis (F, arrows) from heart were found in aged tissues from Tpcn2−/− mice. Scale bars, 50 μm.