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Histopathological micrographs of aged tissues. A–F, representative trichrome staining of spleen (A and B), liver (C and D), and heart (E and F) derived from 22-month-old wild type (A, C, and E) or Tpcn2−/− (B, D, and F) mice. Abundant empty vacuoles (B, arrows) from spleen, lipofuscin deposits (D, arrows) from liver, and fibrosis (F, arrows) from heart were found in aged tissues from Tpcn2−/− mice. Scale bars, 50 μm.
