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. 2014 Dec 10;290(6):3455–3467. doi: 10.1074/jbc.M114.605253

FIGURE 5.

FIGURE 5.

Depletion of nSMase1 and nSMase2 reduces exosome release. A, AChE quantification of exosomes from nSMase1B and nSMase1C, revealing a decrease in exosome release upon nSMase1 KD. The decrease for non-infected nSMase1B exosomes is close to, but did not achieve statistical significance (p < 0.094). B, AChE quantification of exosomes from nSMase2A and nSMase2B, also revealing a decrease in exosome release upon nSMase2 KD, although the decrease is slightly less from prion-infected than non-infected cells. The decrease for non-infected nSMase2B and prion-infected nSMase2A exosomes is close to, but did not achieve statistical significance (p < 0.078 and p < 0.061, respectively). Data presented as mean ± S.E., n = 3, *, p < 0.05.