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Structures of class F GPCR CRDs. A, the structure of the mouse Frizzled-8 CRD (Fz8 CRD) shown with the palmitoleic acid moiety (PAM) in red (PDB: 4F0A). The position of Xenopus Wnt8 loop to which PAM is attached is noted by a dashed black line. B, the structure of the zebrafish Smoothened CRD with residues implicated in binding 20(S)-OHC shown in red (PDB: 4C79).
