FIGURE 1.

Schematic representation of the domain structure of NG2 and the purified NG2 ectodomain fragments. The residue numbering is shown at the top. SP, TM, and CT, the signal peptide, the transmembrane domain, and the cytoplasmic tail, respectively. EC, the full-length NG2 ectodomain; ECΔ3, the NG2 ectodomain lacking D3; D2, central domain 2 of NG2; D3, juxtamembrane domain 3 of NG2. The numbers at the beginning and end of each construct refer to the residue numbering. The arrows indicate the putative MMP-14 cleavage site in the D1 domain.