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. Author manuscript; available in PMC: 2016 Feb 4.
Published in final edited form as: Neuron. 2015 Feb 4;85(3):561–572. doi: 10.1016/j.neuron.2014.12.058

Figure 4.

Figure 4

Brainstem cholinergic neuron ceases firing during partial seizure.

(A) Cholinergic neuron in PPT dramatically decreases firing during seizure activity. Expanded segments of baseline, seizure, and postictal recordings from the boxed regions in (A) as well as a recovery period 7 minutes after the stimulus.

(B) Labeled cholinergic cell recorded in (A) stained for Neurobiotin in left panel, choline acetyltransferase (ChAT) in middle panel, and merge in right panel. Scale bars are 20 micrometers. HC, hippocampus; PPT, pedunculopontine tegmental nucleus; LO, lateral orbitofrontal cortex; LFP, local field potential; SUA, single unit (juxtacellular) activity; MUA, multiunit activity. See also Figures S2