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Epithelial Na+ channel structure. ENaCs are composed of three subunits: α, β, and γ, and transport salt in a variety of epithelial tissues in the body. The α subunit alone is capable of functioning as a sodium transporter, but the addition of β and γ subunits increase the efficiency of this process. Sodium transport activity of ENaCs can be blocked with amiloride or enhanced with AVP.
