Alendronate |
10 mg/day or 70mg/week orally |
Heartburn, dyspepsia, musculo-skeletal pain, oesophagitis and oesophageal ulceration. Cumulative toxicity in CKD ≥ stage 4. Osteonecrosis of jaw can occur with dental procedures |
Risedronate |
5 mg/day or 35 mg/week orally |
Similar to alendronate and skin rash and arthralgia |
Ibadronate |
150 mg/month orally or 3 mg intravenously every 3 months |
Dyspepsia, hypophosphatemia, Hypo-calcaemia, flu-like symptoms, oesophagitis |
Zoledronic acid |
5 mg intravenously annually |
GI side effects are less common. Flu-like symptoms for up to 3 days of infusion. |