Table 1.
Patient characteristics
| Translocation/rearrangement | Patient ID | Age at diagnosis (months) | Gender | WBC (×103/µL) | Extramedullary involvement | Specimen type | % in human CD45+ | % in human CD34+CD38+ | % in human CD34− | % in human CD34+38− | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CNS | Testis | Skin | LN | Hepato- megaly (cm) | Spleno- megaly (cm) | CD34+CD38− | CD34+CD38+ | CD34−CD38+ | CD19+CD33− | CD19+CD33+ | CD19−CD33+ | CD19+CD33− | CD19+CD33+ | CD19−CD33+ | CD19+CD33− | CD19+CD33+ | CD19−CD33+ | CD19−CD33− | ||||||
| t(4;11)/MLL-AF4 | 1 | 6 | Female | 262.0 | (−) | (−) | (−) | (−) | 3 | 5 | PB | 1.0 | 96.4 | 2.0 | 86.3 | 11.0 | 1.7 | 62.2 | 1.1 | 17.2 | 65.1 | 4.3 | 3.5 | 27.2 |
| 2 | 5 | Female | 59.0 | (−) | (−) | (−) | (−) | 4 | 3 | PB | 0.3 | 42.5 | 43.4 | 77.4 | 19.5 | 1.5 | 36.6 | 9.2 | 45.2 | 42.8 | 1.0 | 17.3 | 38.9 | |
| 3 | 4 | Female | 176.7 | (−) | (−) | (−) | (−) | 2 | 2 | PB | 0.3 | 55.2 | 43.4 | 75.8 | 22.0 | 1.0 | 30.8 | 44.3 | 12.0 | 26.0 | 0.4 | 20.3 | 53.3 | |
| 4 | 4 | Female | 403.5 | (−) | (−) | (−) | (−) | 3 | 3 | PB | 0.6 | 43.4 | 54.6 | 96.2 | 2.8 | 0.1 | 94.0 | 2.7 | 1.0 | 63.8 | 0.6 | 3.5 | 32.2 | |
| 5 | 1 | Female | 398.0 | + | (−) | (−) | (−) | 4 | 6 | PB | 0.3 | 89.1 | 10.1 | 94.9 | 0.6 | 0.1 | 87.6 | 3.9 | 2.1 | 47.1 | 0.0 | 1.3 | 51.6 | |
| 6 | 1 | Male | 328.8 | (−) | (−) | + | (−) | 5 | 5 | PB | 0.5 | 65.8 | 29.0 | 62.2 | 12.8 | 0.7 | 50.6 | 10.9 | 17.8 | 16.8 | 0.3 | 40.3 | 42.6 | |
| 7 | 8 | Female | 166.4 | + | (−) | (−) | (−) | 5 | 5 | PB | 2.3 | 42.2 | 48.2 | 70.7 | 28.1 | 0.7 | 45.9 | 51.5 | 0.7 | 37.1 | 35.5 | 14.4 | 13.0 | |
| 8 | 4 | Male | 1290.0 | (−) | (−) | (−) | (−) | 6 | 7 | BM | 0.4 | 56.4 | 43.0 | 83.5 | 8.7 | 0.1 | 86.7 | 9.9 | 0.6 | 71.4 | 9.5 | 9.5 | 9.5 | |
| 9 | 3 | Female | 223.5 | + | (−) | (−) | (−) | 5 | 8 | BM | 1.0 | 51.9 | 46.2 | 13.4 | 85.9 | 0.6 | 13.5 | 50.3 | 35.8 | 84.0 | 9.0 | 2.0 | 5.0 | |
| 10 | 3 | Female | 294.0 | + | (−) | (−) | + | 7 | 4 | PB | 0.1 | 52.2 | 47.5 | 97.5 | 1.7 | 0.3 | 91.8 | 6.6 | 1.1 | 27.5 | 0.0 | 5.0 | 67.5 | |
| 11 | 6 | Female | 161.2 | (−) | (−) | (−) | (−) | 2 | 5 | BM | 0.7 | 74.8 | 20.1 | 87.1 | 12.8 | 0.1 | 71.8 | 24.5 | 0.8 | 29.4 | 0.0 | 0.0 | 70.6 | |
| 12 | 5 | Male | 832.8 | (−) | (−) | (−) | (−) | 10 | 10 | PB | 0.7 | 95.2 | 3.8 | 87.0 | 4.5 | 2.1 | 51.4 | 4.7 | 28.6 | 44.1 | 1.2 | 12.4 | 42.2 | |
| 13 | 2 | Male | 257.4 | + | (−) | (−) | (−) | 4 | 6 | PB | 1.3 | 47.6 | 49.8 | 89.9 | 7.5 | 0.6 | 66.4 | 19.4 | 6.0 | 75.1 | 1.8 | 6.7 | 16.4 | |
| 25 | 6 | Female | 67.6 | (−) | (−) | (−) | (−) | 1 | 1 | PB | 1.5 | 77.2 | 19.5 | 87.6 | 4.2 | 2.6 | 61.5 | 3.8 | 25.1 | 10.5 | 1.7 | 51.9 | 1.7 | |
| t(9;11)/MLL-AF9 | 14 | 7 | Male | 142.4 | (−) | + | + | + | 5 | 4 | BM | 0.5 | 0.8 | 95.4 | 27.8 | 4.4 | 22.7 | 94.7 | 0.2 | 0.2 | 0.7 | 0.2 | 2.6 | 96.5 |
| 15 | 9 | Female | 97.4 | (−) | (−) | + | (−) | 2 | 0 | PB | 0.3 | 0.4 | 98.8 | n.a. | n.a. | n.a. | 72.9 | 23.6 | 1.7 | 0.0 | 0.2 | 34.9 | 64.9 | |
| 16 | 1 | Male | 473.5 | + | (−) | + | (−) | 4 | 0 | BM | 0.5 | 1.2 | 97.7 | 67.5 | 9.3 | 1.1 | 97.9 | 0.3 | 0.3 | 3.2 | 0.5 | 0.5 | 95.8 | |
| 17 | 6 | Male | 33.0 | (−) | (−) | (−) | (−) | 0 | 0 | BM | 0.1 | 0.1 | 99.2 | n.a. | n.a. | n.a. | 77.1 | 8.6 | 0.7 | 1.5 | 3.0 | 0.0 | 95.5 | |
| 26 | 5 | Male | 2.4 | (−) | (−) | (−) | + | 3 | 2 | BM | 0.0 | 5.5 | 92.9 | 11.2 | 24.1 | 61.2 | 73.7 | 12.9 | 4.0 | n.a. | n.a. | n.a. | n.a. | |
| 27 | 2 | Female | 270.0 | (−) | (−) | + | + | 4 | 3 | BM | 0.0 | 0.1 | 99.8 | n.a. | n.a. | n.a. | 95.1 | 4.1 | 0.3 | n.a. | n.a. | n.a. | n.a. | |
| 28 | 5 | Female | 1.7 | (−) | (−) | (−) | (−) | 1 | 0 | BM | 0.0 | 0.1 | 99.1 | n.a. | n.a. | n.a. | 89.6 | 0.4 | 0.0 | n.a. | n.a. | n.a. | n.a. | |
| t(11;19)/MLL-ENL | 18 | 12 | Female | 499.5 | (−) | (−) | (−) | (−) | 2 | 2 | BM | 1.0 | 90.0 | 8.5 | 96.0 | 0.9 | 0.0 | 90.0 | 1.6 | 0.1 | 87.5 | 0.9 | 0.2 | 11.5 |
| 19 | 5 | Male | 261.6 | (−) | (−) | (−) | (−) | 7 | 5 | PB | 0.1 | 0.1 | 97.7 | n.a. | n.a. | n.a. | 87.9 | 0.0 | 0.3 | 0.0 | 0.0 | 0.0 | 100.0 | |
| 20 | 4 | Female | 60.4 | (−) | (−) | + | + | 5 | 5 | BM | 0.2 | 0.3 | 82.4 | 30.0 | 0.2 | 1.0 | 94.5 | 0.1 | 0.1 | 2.0 | 0.2 | 0.0 | 97.8 | |
| 21 | 3 | Female | 215.1 | (−) | (−) | (−) | (−) | 6 | 4 | BM | 2.9 | 90.2 | 4.5 | 90.9 | 8.1 | 0.5 | 45.4 | 8.4 | 32.9 | 82.4 | 0.5 | 2.3 | 14.8 | |
| 22 | 6 | Male | 993.0 | (−) | + | + | + | 3 | 8 | BM | 0.2 | 79.9 | 19.5 | 98.7 | 0.7 | 0.1 | 94.9 | 0.2 | 0.6 | 52.8 | 0.0 | 5.6 | 41.7 | |
| 23 | 1 | Female | 1750.0 | + | (−) | (−) | (−) | 7 | 7 | PB | 0.1 | 97.1 | 2.8 | 39.9 | 40.4 | 5.3 | 8.2 | 24.3 | 53.0 | 28.6 | 14.3 | 0.0 | 57.1 | |
| 24 | 5 | Female | 123.1 | (−) | (−) | (−) | (−) | 4 | 5 | PB | 0.6 | 95.1 | 3.4 | 80.4 | 11.5 | 0.2 | 75.7 | 7.7 | 4.2 | 56.5 | 3.2 | 0.0 | 40.3 | |
| Normal CB MNCs | 1 | 0 | CB | 0.0 | 0.1 | 60.1 | 39.9 | |||||||||||||||||
| 2 | 0 | CB | 0.0 | 0.5 | 66.4 | 33.1 | ||||||||||||||||||
| 3 | 0 | CB | 0.0 | 0.0 | 29.2 | 70.8 | ||||||||||||||||||
CNS, central nervous system; LN, lymph node; n.a., frequency not available due to low frequency of parent population; WBC, white blood cell count; (−), absence of extramedullary disease; +, presence of extramedullary disease.