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Design of intravital microscopy study of the liver: After animals were instrumented for intensive care set-up, 3 groups were randomized: 1. Control group without hyperinflammation or treatment, 2. LPS group with hyperinflammation and placebo therapy, and 3. LPS + PD-4-I group with hyperinflammation and rolipram therapy (each n = 5-6). Laparotomy and intravital microscopy were performed; afterwards organs and blood were harvested
