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. 2015 Jan 19;194(4):1702–1716. doi: 10.4049/jimmunol.1402244

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Copyright © 2015 The Authors

This is an open-access article distributed under the terms of the CC-BY 3.0 Unported license.

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FIGURE 1. — Cynomolgus macaques develop eschars at the ID inoculation site of O. tsutsugamushi Karp strain. Eschars developed at the ID inoculation site of O. tsutsugamushi Karp strain, on the left inner thigh in cynomolgus macaques. (A–D, F, and H) The eschar images represent the most prominent eschars observed in each group, that is, with the highest eschar scoring value, based on induration, ulceration, and inflammation (between days 14 and 19 after inoculation), or the lowest score achieved as a result of vaccination-associated immune response (E and G). Two representative images are shown per vaccine group. (A and B) Pictures of macaques in the control group (group 1, n = 6). (C) and (D) show macaques inoculated with the Kp47/47-VRP vaccine (group 2, n = 2), (E) and (F) received the pKarp47 vaccine as a triple-homologous prime-boost regimen (group 3, n = 6), and (G) and (H) received pKarp47 vaccine twice and a third boost with the Kp47/47-VRP vaccine candidate, as a heterologous prime-boost regimen (group 4, n = 6).