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. 2015 Jan 19;194(4):1702–1716. doi: 10.4049/jimmunol.1402244

Table I. Overview of cynomolgus macaques (NHPs), vaccine groups, and dermal inoculation-site observations.

Draize Scores
Edemaa
Erythemab
Eschar
Lymphadenopathy
Vaccine Group Vaccine NHP ID Inoc. No. Max. Score Days Max. Score Days Max. Score Days Regional General
Group 1a None (PBS) 8749 9 B B B D2 5 16
None (PBS) 6741 3 3 12–14 3 12–16 3 12–19 5 7
Group 1b None (pVR1012) 5671 8 3 12–14 3 9–14 3 12–16 5 9
Group 1c None (pGM-CSF) 8824 12 3 12–14 3 12–14 3 9–14 7 16
None (pGM-CSF) 5199 6 3 12–14 4 14–16 3 12–19 5 16
Group 1d None (mSEB-VRP) 6856 18 B B B D7 5 9
Group 2 Kp47/47-VRP 5747 4 3 9–16 4 9–14 4 9–16 5 16
Kp47/47-VRP 8984 10 3 9–14 4 9–14 4 12–14 5 7
Group 3.1 pKarp47 (2 mg ×3) 6537 13 0 0 NE 5 16
pKarp47 (2 mg ×3) 5732 1 3 12–16 3 14–16 3 16–21 5 16
Group 3.2 pKarp47 (1 mg ×3) 5253 19 B B B D2 7 7
pKarp47 (1 mg ×3) 7416 7 3 16–19 3 16–19 NE 9 16
Group 3.3 pKarp47 (0.5 mg ×3) 5817 15 0 0 NE 7 28
pKarp47 (0.5 mg ×3) 5601 16 0 0 NE 7 14
Group 4.1 pKarp47 (2 mg ×2+VRP) 5689 2 2 12–14 2 12–14 NE 5 9
pKarp47 (2 mg ×2+VRP) 6985 14 3 16–19 3 16–19 3 16–23 5 7
Group 4.2 pKarp47 (1 mg ×2+Kp47/47-VRP) 2660 20 0 0 NE 5 19
pKarp47 (1 mg ×2+Kp47/47-VRP) 5234 5 B B B D7 5 9
Group 4.3 pKarp47 (0.5 mg ×2+Kp47/47-VRP) 5235 11 2 14–16 3 12–14 3 12–19 5 12
pKarp47 (0.5 mg ×2+Kp47/47VRP) 7982 17 3 16–19 4 16–19 4 16–26 5 12

Highest scores for edema, erythema, and eschar are noted and time period they were observed in days postinoculation. Lymphadenopathy denotes the first day of clinical enlargement of regional (draining) lymph nodes and generalized lymph nodes.

a

Edema scores: 0, none (no swelling); 1, minimal (slight swelling); 2, mild (defined swelling [distinct]); 3, moderate (defined swelling [raised]). Erythema scores: 0, none (normal color); 1, minimal (light pink); 2, mild (bright pink/pale red); 3, moderate (bright red); 4, severe (dark red).

b

Eschar scores: 1, papule (induration and inflammation); 2, excoriation (induration and central lesion); 3, central necrosis (central lesion with raised induration around the lesion, <10 mm); 4, central necrosis and raised induration (large central ulceration and black crust, >10 mm).

B, biopsy; Inoc., inoculation; Max. maximum; NE, no eschar.