Table III. Phenotypic correlates associated with immune protection.

Sterile immunity	Absence of bacteremia in the presence of cellular and humoral immunity
Fever	Delayed onset, with right shift or protracted fever curves, and reduction of fever AUC
Eschar	Absence of eschars, delayed time to onset, decreased size and severity score
Bacteremia	Reduction of duration, TTB, and total bacterial biomass (AUC)
Biochemistry markers	Total protein, albumin, albumin/globulin ratio, and liver transaminases

These phenotypic markers were significantly associated with immune protection associated with high frequencies of IFN-γ–secreting, Ag-specific T cell responses in cynomolgus macaques.