Table 2.
Univariate association of patient and family factors with anxiety and depression
| Anxiety | Depression | |||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Age group at diagnosis | ||||
| Pre-school (ages 2–4) | Reference group | Reference group | ||
| School-age (ages 5–12) | 0.62 (0.37,1.05) | 0.076 | 0.78 (0.49,1.26) | 0.314 |
| Gender | ||||
| Male | Reference group | Reference group | ||
| Female | 1.62 (0.97,2.72) | 0.067 | 1.27 (0.79,2.02) | 0.325 |
| Race/Ethnicity | ||||
| White, non-Hispanic | Reference group | Reference group | ||
| Hispanic | 3.32 (1.80,6.15) | 0.000 | 1.36 (0.73,2.53) | 0.335 |
| Black, non-Hispanic | 0.83 (0.23,2.96) | 0.769 | 1.22 (0.46,3.25) | 0.696 |
| Other | 1.61 (0.68,3.83) | 0.277 | 1.59 (0.75,3.37) | 0.226 |
| Annual family income | ||||
| ≥$50,000 | Reference group | Reference group | ||
| <$50,000 | 1.11 (0.63,1.98) | 0.720 | 1.17 (0.68,2.01) | 0.564 |
| Maternal education | ||||
| At least some college | Reference group | Reference group | ||
| Less than college | 1.15 (0.64,2.04) | 0.642 | 1.24 (0.74,2.09) | 0.410 |
| Marital status of parents | ||||
| Married | Reference group | Reference group | ||
| Not married | 1.30 (0.74,2.29) | 0.354 | 1.65 (0.99,2.75) | 0.054 |
| General Family Functioning1 | ||||
| Healthy family functioning | Reference group | Reference group | ||
| Unhealthy family functioning | 3.01 (1.76,5.15) | <0.001 | 2.37 (1.45,3.85) | 0.001 |
| Maintaining family integration coping behaviors2 | 0.97 (0.94,0.99) | 0.009 | 0.96 (0.94,0.98) | 0.001 |
| Maintaining social support coping behaviors3 | 0.96 (0.94,0.99) | 0.005 | 0.95 (0.93,0.97) | <0.001 |
| Understanding the medical situation coping behaviors4 | 0.95 (0.90,1.00) | 0.038 | 0.93 (0.89,0.98) | 0.003 |
| Pain and hurt by parental report5 | 0.99 (0.98,1.00) | 0.062 | 0.99 (0.98,1.00) | 0.016 |
| Nausea by parental report6 | 0.99 (0.97,1.01) | 0.186 | 0.99 (0.98,1.01) | 0.230 |
| Therapeutic randomization7 | ||||
| SC/SIM-SDI | Reference group | Reference group | ||
| IC/SIM-SDI | 1.20 (0.60,2.40) | 0.598 | 0.95 (0.50,1.78) | 0.862 |
| SC/AIM-ADI | 1.23 (0.59,2.57) | 0.585 | 1.00 (0.51,1.95) | 0.991 |
| IC/AIM-ADI | 1.02 (0.45,2.28) | 0.970 | 1.14 (0.56,2.33) | 0.713 |
1
Measured by the FAD-GF.
2
Measured by the CHIP subscale 1.
3
Measured by the CHIP subscale 2.
4
Measured by the CHIP subscale
5
Measured by the PedsQL pain and hurt scale
6
Measured by the PedsQL nausea scale
7
SC = Standard Consolidation, IC = Intensified Consolidation, SIM-SDI = Standard Interim Maintenance and Standard Delayed Intensification, AIM-ADI = Augmented Interim Maintenance and Augmented Delayed Intensification