Table 3.
Rnd interacting partners and their functions.
| Rnd partner | Rnd | Function | References |
|---|---|---|---|
| p190RhoGAP | Rnd1 | Down-regulation of RhoA in stress fiber collapse and during cortical neuron migration | 1, 2, 3, 4 |
| Rnd2 | |||
| Rnd3 | |||
| ROCKI | Rnd3 | Inhibition of ROCKI signaling in stress fiber disassembly; control of Rnd localization and stability through phosphorylation | 5, 6 |
| Syx | Rnd3 | Down-regulation of RhoA in Zebrafish gastrulation | 7 |
| MgcRacGAP | Rnd2 | Regulation of RhoGTPase flux during cytokinesis; control of male germ cell development | 8, 9 |
| PlexinB2 | Rnd3 | Regulation of neuronal migration by fine-tuning RhoA signaling | 4 |
| PlexinB1 | Rnd1 | Activation of RhoA and down-regulation of R-Ras in growth cone collapse | 10, 11 |
| PlexinD1 | Rnd2 | Down-regulation of R-Ras in axon outgrowth inhibition | 12 |
| PlexinA1 | Rnd1 | Activation of Rac1 and down-regulation of R-Ras in axonal repulsion | 13, 14, 15 |
| Rapostilin | Rnd2 | Regulation of endocystosis and membrane invagination in neurite branching and spine formation | 16, 17 |
| Vps4A | Rnd2 | Regulation of endosomal trafficking | 18 |
| FLRT3 | Rnd1 | Control of cadherin-mediated adhesion during Xenopus gastrulation | 19, 20 |
| Pragmin | Rnd2 | Activation of RhoA in neurite outgrowth inhibition | 21 |
| SCG10 | Rnd1 | Control of microtubule stability in axon formation | 22 |
| Socius | Rnd1 | Loss of stress fibers | 23 |
| FSR2a/b | Rnd1 | Control of neurite extension downstream of FGF signaling | 24 |
| Grb7 | Rnd1 | Possible role in migration/invasion | 25 |
| STI1 | Rnd1 | Control of cytoskeletal collapse | 26 |
1 (Foster et al., 1996), 2 (Wennerberg et al., 2003), 3 (Pacary et al., 2011), 4 (Azzarelli et al., 2014) 5 (Riento et al., 2003), 6 (Riento et al., 2005), 7 (Goh and Manser, 2010), 8 (Naud et al., 2003), 9 (Miller and Bement, 2009), 10 (Oinuma et al., 2003), 11 (Oinuma et al., 2004), 12 (Uesugi et al., 2009), 13 (Rohm et al., 2000), 14 (Toyofuku et al., 2005), 15 (Zanata et al., 2002), 16 (Fujita et al., 2002), 17 (Wakita et al., 2011), 18 (Tanaka et al., 2002), 19 (Karaulanov et al., 2009), 20 (Ogata et al., 2007), 21(Tanaka et al., 2006), 22 (Li et al., 2009), 23 (Katoh et al., 2002), 24 (Harada et al., 2005), 25 (Vayssiere et al., 2000), 26 (De Souza et al., 2014).