Table 1.
Signaling pathways associated with cognitive enhancement in animal models.
| Pathway name | Overlap with gene list (%) | Odds ratio | p-value |
|---|---|---|---|
| IP3 pathway (gene expression) | 25.9 | 0.346 | 1.53E-08 |
| IGF1R pathway (cell survival) | 17.9 | 0.215 | 2.39E-07 |
| cAMP pathway (axonal growth) | 20.8 | 0.245 | 6.88E-06 |
| IGF1R main pathway | 6.6 | 0.073 | 2.09E-05 |
| IP3 main pathway | 5.2 | 0.058 | 0.000142525 |
| IL-2 main pathway | 4.4 | 0.044 | 0.002495586 |
| Wnt main pathway | 2.8 | 0.029 | 0.028947377 |
| GPCR main pathway | 2.5 | 0.025 | 0.033190669 |
| cAMP main pathway | 2.1 | 0.021 | 0.034326773 |
Gene set enrichment analyses of the genes implicated in cognitive performance against Insilico Cloud Intelligence signaling pathway database performed using Fisher’s exact test and the most enriched pathways.