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. 2014 Dec 22;125(2):551–562. doi: 10.1172/JCI78470

Figure 5. GLS-dependent Gln catabolism is required for WNT-induced ISR and osteoblast differentiation.

Figure 5

(AD) Effect of BPTES treatment on WNT-induced Gln consumption (A), gene expression (B and C), or AKP2 and von Kossa staining (D). (EH) Effect of DM-α-KG on WNT-induced Gln consumption (E), GCN2 phosphorylation (F), anabolic gene expression (G), or AKP2 and von Kossa staining (H). Error bars indicate SD. *P < 0.05, Student’s t test. n = 3.