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. 2015 Jan 9;125(2):636–651. doi: 10.1172/JCI77435

Figure 7. Diagram summarizing interaction network potentially encompassing all the proteins encoded by the genes identified in the study.

Figure 7

Three categories of cellular functions (sister chromatid cohesion, chromatin remodeling, and transcriptional regulation) are shown. The proteins are illustrated in colored spheres. NIPBL, SMC1A, SMC3, and RAD21 are the 4 components in cohesin, which is involved in sister chromatid cohesion, chromatin remodeling, and transcriptional regulation. The interaction between trithorax-group proteins and the RAD21 links KMT2A into this interaction network. RNA Pol II interacts with both TFIID and cohesin and then potentially links TAF6, a core component of TFIID complex, to the cohesin.