Figure 1. Foxp3-Cre–mediated Hsp90b1 deletion in mice causes a fatal inflammatory disease.

(A) Rapid loss of body weight of KO mice (right) compared with WT littermates (left). (B) Survival rate of WT (n = 7), Het (n = 10), and KO (n = 18) mice. Mouse survival data was analyzed by a log-rank (Mantel-Cox) test. (C) H&E staining of sections of indicated organs from 7-week-old KO mice and WT littermates. Representative results from multiple mice (n > 3) are shown.