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. 2015 Jan 9;125(2):665–680. doi: 10.1172/JCI78253

Figure 4. UCP2 regulates lipid synthesis via FASN in macrophages.

Figure 4

(A) TGs in Ucp2+/+ or Ucp2–/– BMDMs treated with LPS (500 ng/ml) for 4 hours. *P < 0.05, ANOVA. (B) 18F-FDG uptake and PEP and lactate production in Ucp2+/+ or Ucp2–/– BMDMs treated with LPS (500 ng/ml) for 4 hours. *P < 0.05, ANOVA. (C) Citrate production in Ucp2+/+ or Ucp2–/– BMDMs treated with LPS (500 ng/ml) for 4 hours. *P < 0.05, ANOVA. (D) Immunoblot analysis for FASN, ACACA, and ACLY in cell lysates from Ucp2+/+ or Ucp2–/– BMDMs treated with LPS (500 ng/ml) for 4 hours. β-Actin served as the standard.