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. 2015 Feb 6;6:13. doi: 10.3389/fendo.2015.00013

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Copyright © 2015 Akintola and van Heemst.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Insulin and the brain: models of accelerated and delayed aging. Figure showing the putative relationship between central insulin action and glucose metabolism in models of accelerated or delayed aging. Obesity as a model for accelerated aging is associated with peripheral insulin resistance, decreased adiponectin levels, and enhanced chronic inflammation. Opposite features are observed in healthy longevity as a model of delayed aging.