Table 1.
Molecular nature of chemical sensors in BK channels*.
| Ligands | Effect | Binding site(s) | References |
|---|---|---|---|
| Ca2+ | Activation | D367, R514, and E535 (in RCK1) and Ca-bowl: D889, D892, D895, and D897 (in RCK2) | Schreiber and Salkoff, 1997; Shi et al., 2002; Xia et al., 2002; Zhang et al., 2010a |
| Mg2+ | Activation | D99 and N172 (in VSD) + E374 and E399 (in RCK1) | Shi et al., 2002; Xia et al., 2002; Yang et al., 2008 |
| H+ | Activation | H365 and H394 (in RCK1) | Hou et al., 2008b |
| Carbon monoxide | Activation | Potentially through H365, D367, and H394 (in RCK1) | Hou et al., 2008a |
| Ethanol | Activation | K361 and R514 (in RCK1) | Bukiya et al., 2014 |
| Heme | Inhibition | C612KAC615H616 (between RCK1 and RCK2) | Tang et al., 2003 |
| PIP2 | Stabilization? | K392, R393 (in RCK1) | Tang et al., 2014 |
| Omega-3 | Activation | Y318 (in S6) | Hoshi et al., 2013d |
*
The residue numbers are according to the sequence of the mbr5 clone.