Figure 3.

FDG-PET exam (left) and FES-PET exam (right) of a woman with metastatic breast cancer. The tumor lesions, assessed with FDG-PET, showed heterogeneous expression of estrogen receptors: primary breast tumor had a high but heterogeneous uptake pattern of FES, mediastinal nodes showed no significant FES uptake, and the bone metastasis on the left ischiopubic branch showed weak FES uptake. The liver metastasis was not evaluable with FES-PET because of the high physiological uptake of the liver (images are obtained from Estrotepredic Programme Hospitalier de Recherche Clinique, coordinator: Dr. K. Kerrou, Hôpital Tenon, Assistance-Publique–Hôpitaux de Paris, Paris; Eudract: 2011-005043-27).

Abbreviations: FDG, fluorodeoxyglucose; FES, 16α-¹⁸F-fluoro-17β-estradiol; PET, positron emission tomography.