Table 2.
Relation of peak arterial pressure response to a dose of phenylephrine (PE) or norepinephrine (NE).
| PE | NE | NC VS CHF | PE VS NE | INTERACTION | |||
|---|---|---|---|---|---|---|---|
| NC (N = 9) | CHF (N = 6) | NC (N = 8) | CHF (N = 5) | ||||
| Slope of linear regression, mmHg/decade | 54.6 ± 4.7 | 37.4 ± 3.9 | 52.5 ± 3.7 | 36.9 ± 5.0 | 0.002 | 0.780 | 0.871 |
| Maximum slope, mmHg/decade | 80.9 ± 6.3 | 57.3 ± 5.2 | 80.4 ± 5.9 | 60.2 ± 7.8 | 0.003 | 0.851 | 0.796 |
| Response range of AP, mmHg | 125.1 ± 8.8 | 89.7 ± 10.1 | 116.0 ± 5.7 | 90.9 ± 14.0 | 0.004 | 0.683 | 0.590 |
| Lower plateau of AP, mmHg | 61.2 ± 4.5 | 67.5 ± 7.8 | 74.3 ± 9.1 | 69.9 ± 9.8 | 0.902 | 0.333 | 0.501 |
| Dose at midpoint, μg/kg | 3.87 ± 0.59 | 6.15 ± 1.26 | 0.51 ± 0.10 | 0.75 ± 0.24 | 0.077 | <0.001 | 0.150 |
Notes: Values are means ± standard error. P value was obtained by two-way analysis of variance.
Abbreviations: NC, normal control; CHF, chronic heart failure; AP, arterial pressure.