Table 1.

Signal transduction events, state variables, and model parameters in the insulin signal transduction pathway.

Reaction	Remarks	Rate constants Forward reactions.	Rate constants Reverse reactions.
1	IR + I ↔ IR-I	k1	km1
2	IR-I + I ↔ IR-I2	k2	km2
3	IR-I, IR-I2 → IR-I-P, IR-I2-P	k3	km3 [PTP]
4	IR-I-P + I ↔ IR-I2-P	k2	km2
5	IR ↔ IRintracellular	k4	km4
6	→ IRintracellular →	k5	km5
7	IR-I, IR-I2 → IRintracellular	k4’
8	IR-I-P, IR-I2-P ↔ IR-I-P intracellular, IR-I2-P intracellular	k4’	km4’
9	IRS 1 ↔> IRS 1-P	k7	km7[PTP]
10	IRS1-P + PI3K ↔ IRS1-P-PI3K	k8	km8
11	PI(4,5)P2 ↔ PI(3,4,5)P3	k9	km9[PTEN]
12	PI(3,4)P2 ↔ PI(3,4,5)P3	k10	km10[SHIP]
13	IRS 1 ↔ IRS1-P’	k113	km113
14	Akt <-> Akt-P	k113	km11
15	Akt-P + AS160 <-> AS160-P	k14a	km14a
16	AS160P + RabGDP<-> RabGTP	k15	km15
17	PKC-P + Munc18c-Syn4-SNAP <-> PKC-P –Munc18c + Syn4-SNAP	k16	km16
18	RabGTP +Glut4 -> Glut4 Translocation	k13p	km13
19	PKC-P-Munc18c + Glut4-> Glut4 Translocation	k13pp	km13

Reactions 1-12 are original equations included in Sedaghat's model (3). Reaction 13—19 are new events incorporated into this expanded model.